Hydrochloric Acid → HCID 15116074, compound

HRID 1498907Notes

Reaction equation

HRID 1498907 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([C:15]([O:17]CC)=[O:16])[N:12]([CH3:14])[N:13]=1.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([C:15]([OH:17])=[O:16])[N:12]([CH3:14])[N:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 82633660Ethyl 3-(2,4-dichlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 15116074HCID 15116074, compoundYield 70.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(2,4-dichlorophenyl)-2-methyl-2H-pyrazole-3-carboxylate (2.98 g) was added to ethanol (50 ml), and sodium hydroxide (5.0 g) was added thereto at a room temperature under stirring, and subsequently the mixture was heated and stirred for 60 minutes. The mixture was adjusted to pH 5 by addition of 2-N hydrochloric acid, and the precipitated crystal was separated by filtration and subjected to through circulation drying to give the title compound (1.90 g, 70%) as a white powder.

Workup

  1. additionwas added
  2. temperaturesubsequently the mixture was heated
  3. stirringstirred for 60 minutes
  4. customthe precipitated crystal was separated by filtration
  5. customdrying

Sources & evidence

ORD record
ord-dc3d2d80647d4b718084c8af9b1a2455
Source dataset
uspto-grants-2015_12
Patent number
US09200008B2

Reaction notes

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