反应详情

Ethyl 5-(2-methoxyphenyl)-2-methylfuran-3-carboxylate (1.00 g, 3.84 mmol) prepared in the Step 20-1-2 was dissolved in ethanol (8 ml), and a 1 mol/ml sodium hydroxide aqueous solution (8 ml) was added thereto. The mixture was heated under reflux for about 40 minutes. After being allowed to cool, the mixture was adjusted to weak acidity with 2 mol/ml hydrochloric acid, and the precipitate was filtered. The residue was washed with water and dried to give the title compound (0.95 g, quantitative) as a white powder.

1. temperatureThe mixture was heated
2. temperatureunder reflux for about 40 minutes
3. temperatureto cool
4. filtrationthe precipitate was filtered
5. washThe residue was washed with water
6. customdried