Isovanillin → HCID 77531995, compound

HRID 1498934Notes

Reaction equation

HRID 1498934 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:10][C:11]([C:15]([NH:17][NH2:18])=[O:16])=[C:12]([CH3:14])[N:13]=1.[OH:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH:23]=O>C(O)C>[OH:19][C:20]1[CH:21]=[C:22]([CH:23]=[N:18][NH:17][C:15]([C:11]2[S:10][C:9]([C:3]3[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])=[N:13][C:12]=2[CH3:14])=[O:16])[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]

Participants

4

Reactant 2

HCID 12127IsovanillinHCID 68642532HCID 68642532, compound

Product 1

HCID 77531995HCID 77531995, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (5 ml), 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylic acid hydrazide (34 mg) and 3-hydroxy-4-methoxybenzaldehyde (19 mg) was heated under reflux for 25 hours. After the mixture was allowed to cool, the precipitated crystal was separated by filtration to give the title compound (42 mg, 86%).

Workup

  1. temperatureunder reflux for 25 hours
  2. temperatureto cool
  3. customthe precipitated crystal was separated by filtration

Sources & evidence

ORD record
ord-8b4bad75250e4c7491903914deabd295
Source dataset
uspto-grants-2015_12
Patent number
US09200008B2

Reaction notes

Loading…