Hydrazine hydrate (1:1) → {1-[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]ethylidene}-hydrazine

Participants

Reaction Steps

In ethanol (10 ml), 1-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]-ethanone (205 mg) prepared in the Step 30-1-1 was dissolved, and hydrazine monohydrate (1.2 g) was added thereto. The mixture was heated under reflux for 21 hours. The mixture was concentrated under a reduced pressure, and then water was added thereto. The precipitated crystal was separated by filtration, washed with water, and dried to give the title compound (196 mg, 91%).

Provenance & Evidence