反应详情

In ethanol (10 ml), 1-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]-ethanone (205 mg) prepared in the Step 30-1-1 was dissolved, and hydrazine monohydrate (1.2 g) was added thereto. The mixture was heated under reflux for 21 hours. The mixture was concentrated under a reduced pressure, and then water was added thereto. The precipitated crystal was separated by filtration, washed with water, and dried to give the title compound (196 mg, 91%).

1. dissolutionwas dissolved
2. temperatureThe mixture was heated
3. temperatureunder reflux for 21 hours
4. concentrationThe mixture was concentrated under a reduced pressure
5. additionwater was added
6. customThe precipitated crystal was separated by filtration
7. washwashed with water
8. customdried