Hydrochloric Acid → HCID 68642024, compound

HRID 1498962Notes

Reaction equation

HRID 1498962 reaction equation
[CH2:1]1[N:6](C(OCC)=O)[CH2:5][CH2:4][N:3]2[C:12]3[CH:18]=[CH:17][C:16]([C:19]([O:21]CC)=[O:20])=[CH:15][C:13]=3[N:14]=[C:2]12.[OH-].[Na+].O.Cl>C(O)C>[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[C:12]3[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][C:13]=3[N:14]=[C:2]12

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68642062HCID 68642062, compound

Product 1

HCID 68642024HCID 68642024, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diethyl 3,4-dihydro-1H-benzo[4,5]imidazo[1,2-a]pyrazine-2,8-dicarboxylate (500 mg, 1.58 mmol) prepared in the Step 38-1-3 was suspended in ethanol (3.2 ml), and a 1 mol/L sodium hydroxide aqueous solution (1.6 ml) and then purified water (1.6 ml) were added thereto. The mixture was heated under reflux for 48 hours. After being allowed to cool, the mixture was neutralized with 3-N hydrochloric acid. The precipitate was separated by filtration and dried to give the title compound (230 mg, 67%) as a light-brown powder.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 48 hours
  3. temperatureto cool
  4. customThe precipitate was separated by filtration
  5. customdried

Sources & evidence

ORD record
ord-9f999eab719842b5a448c09c52a6c0b8
Source dataset
uspto-grants-2015_12
Patent number
US09200008B2

Reaction notes

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