Ammonia → HCID 68088721, compound

Participants

Reaction Steps

A round-bottomed flask was loaded up with 3-amino-6-methyl-furo[2,3-d]pyridine-2-carboxylic acid ethyl ester, 16 (926 mg, 4.20 mmol, 1 eq) and urea (2.52 g, 42.0mmol, 10 eq). The mixture was heated up at 190° C. for 3 h until no more ammonia release was observed. H2O (10 mL) was added, and the reaction mixture was stirred for 30 min vigorously; it was then filtered, and the solid was washed with H2O (3×10 mL) before drying to furnish the product as a pale brown solid (1.60 g, quant.)

Provenance & Evidence