Ammonia → HCID 68088721, compound

HRID 1499025Notes

Reaction equation

HRID 1499025 reaction equation
C(O[C:4]([C:6]1[O:15][C:9]2=[CH:10][C:11]([CH3:14])=[N:12][CH:13]=[C:8]2[C:7]=1[NH2:16])=[O:5])C.[NH2:17][C:18](N)=[O:19].N>O>[CH3:14][C:11]1[CH:10]=[CH:9][C:8]2[C:7]3[NH:16][C:18](=[O:19])[NH:17][C:4](=[O:5])[C:6]=3[O:15][C:13]=2[N:12]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 1176UreaHCID 68088838HCID 68088838, compound

Product 1

HCID 68088721HCID 68088721, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A round-bottomed flask was loaded up with 3-amino-6-methyl-furo[2,3-d]pyridine-2-carboxylic acid ethyl ester, 16 (926 mg, 4.20 mmol, 1 eq) and urea (2.52 g, 42.0mmol, 10 eq). The mixture was heated up at 190° C. for 3 h until no more ammonia release was observed. H2O (10 mL) was added, and the reaction mixture was stirred for 30 min vigorously; it was then filtered, and the solid was washed with H2O (3×10 mL) before drying to furnish the product as a pale brown solid (1.60 g, quant.)

Workup

  1. filtrationit was then filtered
  2. washthe solid was washed with H2O (3×10 mL)
  3. custombefore drying

Sources & evidence

ORD record
ord-1e7ab8edcfdd40d6bc8fa6414ff8543c
Source dataset
uspto-grants-2015_12
Patent number
US09200007B2

Reaction notes

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