Lithium Hydroxide → HCID 117952292, compound

HRID 1499165Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:22][CH2:21][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([O:18]CC)=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:23][CH:24]([C:29]2[CH:34]=[CH:33][C:32]([C:35](=[O:37])[NH2:36])=[CH:31][C:30]=2[N:38]2[CH:42]=[CH:41][C:40]([CH3:43])=[N:39]2)[C:25]([F:28])([F:27])[F:26])[N:3]=1.[Li+].[OH-]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:22][CH2:21][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:23][C@H:24]([C:29]2[CH:34]=[CH:33][C:32]([C:35](=[O:37])[NH2:36])=[CH:31][C:30]=2[N:38]2[CH:42]=[CH:41][C:40]([CH3:43])=[N:39]2)[C:25]([F:28])([F:27])[F:26])[N:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 131734244HCID 131734244, compound

Product 1

HCID 117952292HCID 117952292, compound

Procedure

Hydrolysis of (3S)-ethyl 8-(2-amino-6-(1-(4-carbamoyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provides the title compound as a white solid.

Sources & evidence

ORD record: ord-85bf6d37f60e4a08b346237ac668a9a2
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

Loading…