Lithium Hydroxide → HCID 117942035, compound

HRID 1499176Notes

Reaction equation

HRID 1499176 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[C:31]([C:33]([O:35]CC)=[O:34])[CH:30]=[CH:29][C:28]=2[N:38]2[CH:42]=[CH:41][C:40]([CH3:43])=[N:39]2)[C:23]([F:26])([F:25])[F:24])[N:3]=1.[Li+].[OH-]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[C:31]([C:33]([OH:35])=[O:34])[CH:30]=[CH:29][C:28]=2[N:38]2[CH:42]=[CH:41][C:40]([CH3:43])=[N:39]2)[C:23]([F:26])([F:25])[F:24])[N:3]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 117942323HCID 117942323, compound

Product 1

HCID 117942035HCID 117942035, compound

Procedure

Hydrolysis of (S)-8-(2-amino-6-((R)-1-(5-(ethoxycarbonyl)-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 23) using the LiOH general method provides the title compound as a white solid.

Sources & evidence

ORD record
ord-a17cf0d07c1e4a1e82a2fbe03fc562aa
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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