Lithium Hydroxide → HCID 117947811, compound

HRID 1499180Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:22][CH2:21][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([O:18]CC)=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:23][C@H:24]([C:29]2[CH:34]=[CH:33][C:32]([CH2:35][N:36]([CH3:38])[CH3:37])=[CH:31][C:30]=2[N:39]2[CH:43]=[CH:42][C:41]([CH3:44])=[N:40]2)[C:25]([F:28])([F:27])[F:26])[N:3]=1.[Li+].[OH-]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:21][CH2:22]2)[CH:5]=[C:4]([O:23][C@H:24]([C:29]2[CH:34]=[CH:33][C:32]([CH2:35][N:36]([CH3:38])[CH3:37])=[CH:31][C:30]=2[N:39]2[CH:43]=[CH:42][C:41]([CH3:44])=[N:40]2)[C:25]([F:28])([F:27])[F:26])[N:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 131734247HCID 131734247, compound

Product 1

HCID 117947811HCID 117947811, compound

Procedure

Hydrolysis of (S)-ethyl 8-(2-amino-6-((R)-1-(4-((dimethylamino)methyl)-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provided the title compound as a white solid.

Sources & evidence

ORD record: ord-eda18d8224674c43bbb9fda97a5ad6ff
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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