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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1499183Generated: October 31, 2026

Lithium Hydroxide → HCID 117951828, compound

https://huagongshe.com/reaction/1499183

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
Reactant(S)-ethyl 8-(6-((R)-1-(4-bromo-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-2-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylateHCID 131734248—
ProductHCID 117951828HCID 117951828—

Reaction Steps

Hydrolysis of (S)-ethyl 8-(6-((R)-1-(4-bromo-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-2-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provided the title compound as an off-white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09199994B2
Source datasetuspto-grants-2015_12
ORD IDord-77bfaa16d2c24dfa9e5d613268aa0c80
Source noteuspto-grants-2015_12