Lithium Hydroxide → HCID 117951828, compound

HRID 1499183Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([O:13][C:14]2[N:19]=[C:18]([CH3:20])[N:17]=[C:16]([N:21]3[CH2:35][CH2:34][C:24]4([CH2:28][NH:27][C@H:26]([C:29]([O:31]CC)=[O:30])[CH2:25]4)[CH2:23][CH2:22]3)[CH:15]=2)[C:9]([F:12])([F:11])[F:10])=[C:4]([N:36]2[CH:40]=[CH:39][C:38]([CH3:41])=[N:37]2)[CH:3]=1.[Li+].[OH-]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([O:13][C:14]2[N:19]=[C:18]([CH3:20])[N:17]=[C:16]([N:21]3[CH2:22][CH2:23][C:24]4([CH2:28][NH:27][C@H:26]([C:29]([OH:31])=[O:30])[CH2:25]4)[CH2:34][CH2:35]3)[CH:15]=2)[C:9]([F:10])([F:11])[F:12])=[C:4]([N:36]2[CH:40]=[CH:39][C:38]([CH3:41])=[N:37]2)[CH:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 131734248(S)-ethyl 8-(6-((R)-1-(4-bromo-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-2-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate

Product 1

HCID 117951828HCID 117951828, compound

Procedure

Hydrolysis of (S)-ethyl 8-(6-((R)-1-(4-bromo-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-2-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provided the title compound as an off-white solid.

Sources & evidence

ORD record: ord-77bfaa16d2c24dfa9e5d613268aa0c80
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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