HCID 117942132, compound → HCID 117951855, compound

HRID 1499196Notes

Reaction equation

HRID 1499196 reaction equation
NC1N=C(N2CCC3(CN[C@H](C(O)=O)C3)CC2)C=C(O[C@H](C2C=C([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[C:45]([O:47][CH2:48][CH3:49])=[O:46])C=CC=2N2C=CC(C)=N2)C(F)(F)F)N=1.[NH2:50][C:51]1[N:56]=[C:55]([N:57]2[CH2:79][CH2:78][C:60]3([CH2:64][N:63](C(OCC4C=CC=CC=4)=O)[C@H:62]([C:75]([OH:77])=[O:76])[CH2:61]3)[CH2:59][CH2:58]2)[CH:54]=[C:53]([O:80][C@H:81]([C:86]2[CH:91]=[CH:90][C:89]([Cl:92])=[CH:88][C:87]=2Br)[C:82]([F:85])([F:84])[F:83])[N:52]=1>>[NH2:50][C:51]1[N:56]=[C:55]([N:57]2[CH2:79][CH2:78][C:60]3([CH2:64][NH:63][C@H:62]([C:75]([OH:77])=[O:76])[CH2:61]3)[CH2:59][CH2:58]2)[CH:54]=[C:53]([O:80][C@H:81]([C:86]2[CH:91]=[CH:90][C:89]([Cl:92])=[CH:88][C:87]=2[C:42]2[CH:43]=[CH:44][CH:39]=[C:40]([C:45]([O:47][CH2:48][CH3:49])=[O:46])[CH:41]=2)[C:82]([F:83])([F:85])[F:84])[N:52]=1

Participants

3

Reactant 2

HCID 117942132HCID 117942132, compoundHCID 117951980HCID 117951980, compound

Product 1

HCID 117951855HCID 117951855, compound

Procedure

The title compound was prepared as described for (S)-8-(2-amino-6-((R)-1-(2′-(ethoxycarbonyl)-4-(3-methyl-1H-pyrazol-1-yl)-[1,1′-biphenyl]-3-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 20) starting with (S)-8-(2-amino-6-((R)-1-(2-bromo-4-chlorophenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2-((benzyloxy)carbonyl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid.

Sources & evidence

ORD record
ord-e77f9506aef944298be8d23da0bbfdfe
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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