Lithium Hydroxide → HCID 117947820, compound

HRID 1499211Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([O:8][C@H:9]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[N:21]2[CH:25]=[CH:24][C:23]([CH3:26])=[N:22]2)[C:10]([F:13])([F:12])[F:11])[N:5]=[C:4]([N:27]2[CH2:41][CH2:40][C:30]3([CH2:34][NH:33][CH:32]([C:35]([O:37]CC)=[O:36])[CH2:31]3)[CH2:29][CH2:28]2)[N:3]=1.[Li+].[OH-]>>[NH2:1][C:2]1[N:7]=[C:6]([O:8][C@H:9]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[N:21]2[CH:25]=[CH:24][C:23]([CH3:26])=[N:22]2)[C:10]([F:12])([F:11])[F:13])[N:5]=[C:4]([N:27]2[CH2:28][CH2:29][C:30]3([CH2:34][NH:33][CH:32]([C:35]([OH:37])=[O:36])[CH2:31]3)[CH2:40][CH2:41]2)[N:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 117951975HCID 117951975, compound

Product 1

HCID 117947820HCID 117947820, compound

Procedure

Hydrolysis of ethyl 8-(4-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provided the title compound as a white solid.

Sources & evidence

ORD record: ord-109a837d02bb43b3a013f29673ee226d
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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