Lithium Hydroxide → HCID 117947796, compound

HRID 1499214Notes

Reaction equation

HRID 1499214 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([O:13][C:14]2[CH:15]=[C:16]([N:20]3[CH2:37][CH2:36][C:23]4([CH2:27][N:26](C(O)=O)[C@H:25]([C:31]([O:33]CC)=[O:32])[CH2:24]4)[CH2:22][CH2:21]3)[N:17]=[N:18][CH:19]=2)[C:9]([F:12])([F:11])[F:10])=[C:4]([N:38]2[CH:42]=[CH:41][C:40]([CH3:43])=[N:39]2)[CH:3]=1.[Li+].[OH-]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([O:13][C:14]2[CH:15]=[C:16]([N:20]3[CH2:37][CH2:36][C:23]4([CH2:27][NH:26][C@H:25]([C:31]([OH:33])=[O:32])[CH2:24]4)[CH2:22][CH2:21]3)[N:17]=[N:18][CH:19]=2)[C:9]([F:10])([F:11])[F:12])=[C:4]([N:38]2[CH:42]=[CH:41][C:40]([CH3:43])=[N:39]2)[CH:3]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 117942360HCID 117942360, compound

Product 1

HCID 117947796HCID 117947796, compound

Procedure

Hydrolysis of (S)-8-(5-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyridazin-3-yl)-3-(ethoxycarbonyl)-2,8-diazaspiro[4.5]decane-2-carboxylic acid using the LiOH general method provided the title compound as an off-white solid.

Sources & evidence

ORD record
ord-dabb33bcea554f19b8bb349c61187ddf
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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