Lithium Hydroxide → 2-((benzyloxy)carbonyl)-8-(4-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyridin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid

HRID 1499217Notes

Reaction equation

HRID 1499217 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([O:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([N:20]3[CH2:44][CH2:43][C:23]4([CH2:27][N:26]([C:28]([O:30][CH2:31][C:32]5[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=5)=[O:29])[CH:25]([C:38]([O:40]CC)=[O:39])[CH2:24]4)[CH2:22][CH2:21]3)[CH:15]=2)[C:9]([F:12])([F:11])[F:10])=[C:4]([N:45]2[CH:49]=[CH:48][C:47]([CH3:50])=[N:46]2)[CH:3]=1.[Li+].[OH-]>>[CH2:31]([O:30][C:28]([N:26]1[CH:25]([C:38]([OH:40])=[O:39])[CH2:24][C:23]2([CH2:43][CH2:44][N:20]([C:16]3[CH:15]=[C:14]([O:13][C@H:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=4[N:45]4[CH:49]=[CH:48][C:47]([CH3:50])=[N:46]4)[C:9]([F:10])([F:12])[F:11])[CH:19]=[CH:18][N:17]=3)[CH2:21][CH2:22]2)[CH2:27]1)=[O:29])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 1179422862-benzyl 3-ethyl 8-(4-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyridin-2-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate

Product 1

HCID 1179421962-((benzyloxy)carbonyl)-8-(4-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyridin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid

Procedure

Hydrolysis of 2-benzyl 3-ethyl 8-(4-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyridin-2-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate using the LiOH general method provided 2-((benzyloxy)carbonyl)-8-(4-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyridin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid.

Sources & evidence

ORD record
ord-a9addad0a83446e991022737e8ce5152
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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