Lithium Hydroxide → HCID 117947821, compound

HRID 1499219Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([O:13][C:14]2[CH:19]=[C:18]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:17]=[C:16]([N:27]3[CH2:41][CH2:40][C:30]4([CH2:34][NH:33][CH:32]([C:35]([O:37]CC)=[O:36])[CH2:31]4)[CH2:29][CH2:28]3)[N:15]=2)[C:9]([F:12])([F:11])[F:10])=[C:4]([N:42]2[CH:46]=[CH:45][C:44]([CH3:47])=[N:43]2)[CH:3]=1.[Li+].[OH-]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([O:13][C:14]2[CH:19]=[C:18]([O:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:17]=[C:16]([N:27]3[CH2:28][CH2:29][C:30]4([CH2:34][NH:33][CH:32]([C:35]([OH:37])=[O:36])[CH2:31]4)[CH2:40][CH2:41]3)[N:15]=2)[C:9]([F:11])([F:10])[F:12])=[C:4]([N:42]2[CH:46]=[CH:45][C:44]([CH3:47])=[N:43]2)[CH:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 117942088HCID 117942088, compound

Product 1

HCID 117947821HCID 117947821, compound

Procedure

Hydrolysis of ethyl 8-(4-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-6-phenoxypyrimidin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provided the title compound as an off-white solid.

Sources & evidence

ORD record: ord-5c57efd3a4914a4d8d33cfd2d8a60a22
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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