Lithium Hydroxide → HCID 117947775, compound

HRID 1499228Notes

Reaction equation

[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:9][C:8]=2[C@@H:19]([O:24][C:25]2[N:30]=[C:29]([NH2:31])[N:28]=[C:27]([N:32]3[CH2:46][CH2:45][C:35]4([CH2:39][NH:38][C@H:37]([C:40]([O:42]CC)=[O:41])[CH2:36]4)[CH2:34][CH2:33]3)[CH:26]=2)[C:20]([F:23])([F:22])[F:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].[OH-]>>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:9][C:8]=2[C@@H:19]([O:24][C:25]2[N:30]=[C:29]([NH2:31])[N:28]=[C:27]([N:32]3[CH2:46][CH2:45][C:35]4([CH2:39][NH:38][C@H:37]([C:40]([OH:42])=[O:41])[CH2:36]4)[CH2:34][CH2:33]3)[CH:26]=2)[C:20]([F:22])([F:23])[F:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 131734252HCID 131734252, compound

Product 1

HCID 117947775HCID 117947775, compound

Procedure

Hydrolysis of (S)-ethyl 8-(6-((R)-1-([1,1′:4′,1″-terphenyl]-2′-yl)-2,2,2-trifluoroethoxy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provided the title compound as a white solid.

Sources & evidence

ORD record: ord-60f73f7fffc94ac88113facc4100eb5d
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199994B2

Reaction notes

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