HRID1499237

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

反应SMILES：CCOC(=O)[C@@H]1CC2(CCN(c3cc(O[C@H](c4ccc(-c5ccc(OC(C)C)cc5)cc4-c4ccccc4)C(F)(F)F)nc(N)n3)CC2)CN1

HCID131734256

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)Oc1ccc(-c2ccc([C@@H](Oc3cc(N4CCC5(CC4)CN[C@H](C(=O)O)C5)nc(N)n3)C(F)(F)F)c(-c3ccccc3)c2)cc1

HCID117952891

未命名化合物

PROCEDURE

实验过程

Hydrolysis of (S)-ethyl 8-(2-amino-6-((R)-2,2,2-trifluoro-1-(4-isopropoxy-[1,1′:3′,1″-terphenyl]-4′-yl)ethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate using the LiOH general method provided the title compound as an off-white solid.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-267457ee27d148b58a56dcedd56acb4a
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09199994B2
来源说明: uspto-grants-2015_12

反应SMILES

[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:22][CH2:21][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([O:18]CC)=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:23][C@H:24]([C:29]2[CH:34]=[CH:33][C:32]([C:35]3[CH:40]=[CH:39][C:38]([O:41][CH:42]([CH3:44])[CH3:43])=[CH:37][CH:36]=3)=[CH:31][C:30]=2[C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[C:25]([F:28])([F:27])[F:26])[N:3]=1.[Li+].[OH-]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:21][CH2:22]2)[CH:5]=[C:4]([O:23][C@H:24]([C:29]2[CH:34]=[CH:33][C:32]([C:35]3[CH:36]=[CH:37][C:38]([O:41][CH:42]([CH3:43])[CH3:44])=[CH:39][CH:40]=3)=[CH:31][C:30]=2[C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[C:25]([F:27])([F:28])[F:26])[N:3]=1