反应详情

温度

160 °C

To a mixture of methyl 2-chloro-4-(methylsulfonyl)benzoate (2.2 g, 8.9 mmol), PhB(OH)2 (1.31 g, 10.8 mmol), DME (12 mL), and 2M Na2CO3 (6 mL) was added Pd(PPh3)4 (515 mg). The mixture was heated for 20 min at 160° C. in a microwave reactor, and then extracted with EtOAc, dried over sodium sulfate and concentrated in vacuo. Purification on normal phase silica gel (hexane/EtOAc) provided methyl 5-(methylsulfonyl)-[1,1′-biphenyl]-2-carboxylate as a white solid.

1. extractionextracted with EtOAc
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated in vacuo
4. customPurification on normal phase silica gel (hexane/EtOAc)