反应详情

Iron powder (0.26 g, 4.6 mmol) was added to a mixture containing tert-butyl 5-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6-nitro-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate (0.60 g, 1.2 mmol), AcOH (9 mL), and water (1 mL). The reaction mixture was stirred at room temperature for 2 h. The solution was filtered and the filtrate was concentrated under reduced pressure. The residue was diluted with EtOAc (50 mL) and filtered. The filtrate was neutralized with saturated aq. NaHCO3. The organic layer was washed with brine, dried with Na2SO4 and concentrated under reduced pressure to give the sub-title compound (0.51 g, 90%). LCMS calc. for C23H38N5O4 (M+H)+: m/z=448.3. Found: 448.1.

1. filtrationThe solution was filtered
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionThe residue was diluted with EtOAc (50 mL)
4. filtrationfiltered
5. washThe organic layer was washed with brine
6. dry with materialdried with Na2SO4
7. concentrationconcentrated under reduced pressure