Tetrahydrofuran → 6-(2,6-Difluoro-4-(methoxymethyl)phenyl)-5-fluoropicolinic acid

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Reaction Steps

The methyl 6-[2,6-difluoro-4-(methoxymethyl)phenyl]-5-fluoropyridine-2-carboxylate was treated with THF (2 mL), MeOH (2 mL) and 1.0 M aq. NaOH (2 mL, 2 mmol) at room temperature for 1 h. The volatile solvents were removed under reduced pressure. The residue was neutralized to pH around 5-6 with 1N HCl. The solids that precipitated were collected by filtration, rinsed with water, and dried to give the sub-title compound as a white solid (374 mg, 98.2%). LCMS calc. for C14H11F3NO3 (M+H)+ m/z=298.1. found: 298.0.

Provenance & Evidence