Hydrochloric Acid → HCID 86677719, compound

HRID 1499792Notes

Reaction equation

HRID 1499792 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:14]([C:16]3[C:17]([O:36][CH3:37])=[C:18]([CH:25]4[CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26]4)[C:19]([CH3:24])=[C:20]([C:22]#[N:23])[CH:21]=3)[CH3:15])[N:9]=[C:10]([CH:11]([F:13])[F:12])[C:3]=12.[ClH:38].O1CCOCC1>C(Cl)Cl>[ClH:38].[ClH:38].[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:14]([C:16]3[C:17]([O:36][CH3:37])=[C:18]([CH:25]4[CH2:28][NH:27][CH2:26]4)[C:19]([CH3:24])=[C:20]([CH:21]=3)[C:22]#[N:23])[CH3:15])[N:9]=[C:10]([CH:11]([F:12])[F:13])[C:3]=12

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86677718HCID 86677718, compound

Product 1

HCID 86677719HCID 86677719, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 3-(3-{1-[4-amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-cyano-2-methoxy-6-methylphenyl)azetidine-1-carboxylate (0.20 g, 0.39 mmol) in methylene chloride (5 mL) was added 4.0 M hydrogen chloride in 1,4-dioxane (0.60 mL, 2.4 mmol). The resulting mixture was stirred at room temp for 3.5 h. The solvents were evaporated and the residue dried in vacuo to give 0.23 g of the product as the HCl salt. LCMS calculated for C20H22F2N7O (M+H)+: m/z=414.2; Found: 414.1.

Workup

  1. customThe solvents were evaporated
  2. customthe residue dried in vacuo

Sources & evidence

ORD record
ord-fc3e55027f864c29b4f846fb1fc4fd05
Source dataset
uspto-grants-2015_12
Patent number
US09199982B2

Reaction notes

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