HCID 86677726, compound → tert-Butyl 3-{3-[1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}azetidine-1-carboxylate

HRID 1499809Notes

Reaction equation

HRID 1499809 reaction equation
[Cl:1][C:2]1[C:3]([F:25])=[C:4]([CH:14]2[CH2:17][N:16]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:15]2)[C:5]([O:11][CH2:12][CH3:13])=[C:6]([CH:8](Cl)[CH3:9])[CH:7]=1.[I:26][C:27]1[C:35]2[C:30](=[N:31][CH:32]=[N:33][C:34]=2[NH2:36])[NH:29][N:28]=1>>[NH2:36][C:34]1[N:33]=[CH:32][N:31]=[C:30]2[N:29]([CH:8]([C:6]3[C:5]([O:11][CH2:12][CH3:13])=[C:4]([CH:14]4[CH2:17][N:16]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:15]4)[C:3]([F:25])=[C:2]([Cl:1])[CH:7]=3)[CH3:9])[N:28]=[C:27]([I:26])[C:35]=12

Participants

3

Reactant 2

HCID 86677726HCID 86677726, compoundHCID 178508725HCID 178508725, compound

Product 1

HCID 86677733tert-Butyl 3-{3-[1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}azetidine-1-carboxylate

Procedure

This compound was prepared using procedures analogous to those for Example 139 step 5, with racemic tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-ethoxy-2-fluorophenyl]azetidine-1-carboxylate from Example 139 Step 4 and 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine as starting materials. LCMS calculated for C23H28ClFIN6O3 (M+H)+: m/z=617.1; Found:617.1

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3af3df5e1bdc46289f1bbca76fbae204
Source dataset
uspto-grants-2015_12
Patent number
US09199982B2

Reaction notes

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