Tert-butyl 4-iodopiperidine-1-carboxylate → tert-Butyl 4-(3-acetyl-5-chloro-2-methoxy-6-methylphenyl)piperidine-1-carboxylate

HRID 1499820Notes

Reaction equation

HRID 1499820 reaction equation
[Cl:1][C:2]1[C:3]([CH3:14])=[C:4](I)[C:5]([O:11][CH3:12])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.I[CH:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]1>>[C:8]([C:6]1[C:5]([O:11][CH3:12])=[C:4]([CH:16]2[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]2)[C:3]([CH3:14])=[C:2]([Cl:1])[CH:7]=1)(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 10892302Tert-butyl 4-iodopiperidine-1-carboxylateHCID 866667971-(5-Chloro-3-iodo-2-methoxy-4-methylphenyl)ethanone

Product 1

HCID 86677742tert-Butyl 4-(3-acetyl-5-chloro-2-methoxy-6-methylphenyl)piperidine-1-carboxylate

Procedure

This compound was prepared using procedures analogous to those for Example 139 step 2 with 1-(5-chloro-3-iodo-2-methoxy-4-methylphenyl)ethanone and tert-butyl 4-iodopiperidine-1-carboxylate as starting materials. LCMS calculated for C20H28ClNO4Na (M+Na)+: m/z=404.1; Found: 404.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a9c548494ae74334abcce583fd8cbb70
Source dataset
uspto-grants-2015_12
Patent number
US09199982B2

Reaction notes

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