Sodium borohydride → 3-[3-Chloro-5-(1-hydroxyethyl)-6-methoxy-2-methylphenyl]cyclobutanol

HRID 1499827Notes

Reaction equation

[C:1]([C:4]1[C:5]([O:17][CH3:18])=[C:6]([CH:12]2[CH2:15][C:14](=[O:16])[CH2:13]2)[C:7]([CH3:11])=[C:8]([Cl:10])[CH:9]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>>[Cl:10][C:8]1[C:7]([CH3:11])=[C:6]([CH:12]2[CH2:13][CH:14]([OH:16])[CH2:15]2)[C:5]([O:17][CH3:18])=[C:4]([CH:1]([OH:3])[CH3:2])[CH:9]=1

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 866777503-(3-Acetyl-5-chloro-2-methoxy-6-methylphenyl)cyclobutanone

Product 1

HCID 866777523-[3-Chloro-5-(1-hydroxyethyl)-6-methoxy-2-methylphenyl]cyclobutanol

Procedure

This compound was prepared according to the procedure of Example 13 step 5, using of 3-(3-acetyl-5-chloro-2-methoxy-6-methylphenyl)cyclobutanone and sodium tetrahydroborate as the starting materials. LCMS calculated for C14H19ClO3Na (M+Na)+: m/z=293.1; Found: 293.1.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-71d09b652be143de9ab2fdb9cf209c4f
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199982B2

Reaction notes

Loading…