反应详情

温度

80 °C

The 4-acetyl-5-hydroxy-2-methylbenzonitrile (6.7 g, 38 mmol) was dissolved in acetic acid (80 mL) and the N-Iodosuccinimide (10.0 g, 46 mmol) was added. The reaction was heated to 80° C. in an oil bath and monitored by LC/MS. After heating for 4 hrs the reaction was complete. This was allowed to cool and was concentrated in vacuo to give a dark oil. The oil was taken up in ethyl acetate and washed with water, sodium bicarbonate (3×, until remained slightly basic), brine, dried over magnesium sulfate and concentrated to give the crude product as a dark oil. The product was purified by FCC on silica gel eluting hexane:ethyl acetate gradient to give 4-acetyl-3-hydroxy-2-iodo-6-methylbenzonitrile as pale yellow solid (7.2 g, 62%). LCMS calculated for C10H9INO2(M+H)+: m/z=301.9; found: 301.9.

1. temperatureAfter heating for 4 hrs the reaction
2. temperatureto cool
3. concentrationwas concentrated in vacuo
4. customto give a dark oil
5. washwashed with water, sodium bicarbonate (3×
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated
8. customto give the crude product as a dark oil
9. customThe product was purified by FCC on silica gel
10. washeluting hexane