1-Bromo-4-iodobenzene → 4'-bromo-[1,1'-Biphenyl]-4-carbonitrile

HRID 1499982Notes

Reaction equation

HRID 1499982 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[C:9]([C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1)#[N:10]>ClC1N=C(Cl)C=C(C2C=CC=CC=2)N=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:14]2[CH:15]=[CH:16][C:11]([C:9]#[N:10])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 115221-Bromo-4-iodobenzeneHCID 27343264-Cyanophenylboronic acid

Product 1

HCID 13944624'-bromo-[1,1'-Biphenyl]-4-carbonitrile

Reagents, catalysts & solvents 1

HCID 2415542,4-Dichloro-6-phenylpyrimidineSolvent2×

Procedure

4-bromo-4′-cyanobiphenyl was synthesized by the same method as in syntheses of 2,4-dichloro-6-phenylpyrimidine in the above (3-1-1), except that 4-bromoiodobenzene was used in place of 2,4,6-trichloropyrimidine and that 4-cyanophenylboronic acid was used in place of phenylboronic acid.

Sources & evidence

ORD record
ord-58606253032a44db9bf11a4308ca0e1d
Source dataset
uspto-grants-2015_12
Patent number
US09203043B2

Reaction notes

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