反应详情

2-Chloro-5-nitropyridine (3.0 g, 18.9 mmol), phenylboronic acid (2.5 g, 20.8 mmol), and tetrakis(triphenylphosphine)palladium (0.2 g, 0.2 mmol) were added to 1,2-dimethoxyethan (30 ml), then degassed and purged with nitrogen three times under reduced pressure. Under nitrogen atmosphere the mixture was stirred at room temperature for 20 minutes, then 1M aqueous sodium carbonate (40 ml) was poured in, and the temperature was raised to 80° C. After the reaction at 80° C. for 6 hours, the mixture was cooled to room temperature and crystallized with addition of water. The precipitated crystals were filtered to give the title compound (3.7 g, 96.8%).

1. customdegassed
2. custompurged with nitrogen three times under reduced pressure
3. addition1M aqueous sodium carbonate (40 ml) was poured in, and the temperature
4. temperaturewas raised to 80° C
5. customAfter the reaction at 80° C. for 6 hours
6. temperaturethe mixture was cooled to room temperature
7. customcrystallized with addition of water
8. filtrationThe precipitated crystals were filtered