Ethyl difluoroacetate → HCID 86713177, compound

HRID 1500291Notes

Reaction equation

HRID 1500291 reaction equation
C(O[C:4](=[O:8])[CH:5]([F:7])[F:6])C.[NH2:9][C@H:10]([CH2:20][F:21])[C@@H:11]([C:13]1[CH:18]=[CH:17][C:16]([I:19])=[CH:15][CH:14]=1)[OH:12]>>[F:7][CH:5]([F:6])[C:4]([NH:9][C@H:10]([CH2:20][F:21])[C@H:11]([OH:12])[C:13]1[CH:14]=[CH:15][C:16]([I:19])=[CH:17][CH:18]=1)=[O:8]

Participants

3

Reactant 2

HCID 9961Ethyl difluoroacetateHCID 45257860(2S,1R)-2-Amino-3-fluoro-1-(4-iodo-phenyl)-propan-1-ol

Product 1

HCID 86713177HCID 86713177, compound

Procedure

Using the same procedure as Step 1 of Example 4 and reacting ethyldifluoroacetate with commercially available (1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol the title compound is obtained (18.3 g): m/z 373 (M+H)+.

Sources & evidence

ORD record
ord-583b234c033746b18a36a322d127868f
Source dataset
uspto-grants-2015_12
Patent number
US09206126B2

Reaction notes

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