HCID 73603447, compound → HCID 73603448, compound

HRID 1500293Notes

Reaction equation

FC(F)C(N[C@H](CF)[C@H](O)C1C=CC(C2C=NC(C3(O)COC3)=CC=2)=CC=1)=O.[F:29][CH:30]([F:57])[C:31]([N:33]1[C@H:37]([CH2:38][F:39])[C@@H:36]([C:40]2[CH:45]=[CH:44][C:43]([C:46]3[CH:47]=[CH:48][C:49]([CH2:52][C:53]#[N:54])=[N:50][CH:51]=3)=[CH:42][CH:41]=2)[O:35]C1(C)C)=[O:32]>>[C:53]([CH2:52][C:49]1[N:50]=[CH:51][C:46]([C:43]2[CH:42]=[CH:41][C:40]([C@@H:36]([OH:35])[C@H:37]([NH:33][C:31](=[O:32])[CH:30]([F:57])[F:29])[CH2:38][F:39])=[CH:45][CH:44]=2)=[CH:47][CH:48]=1)#[N:54]

Participants

Reactant 2

HCID 73603447HCID 73603447, compound

HCID 86713180HCID 86713180, compound

Product 1

HCID 73603448HCID 73603448, compound

Procedure

The product of Step 6 of Example 8 and the product of Step 1 of Example 15 are reacted using the same procedure as step 6—Example 8 and making non-critical variations the title compound is obtained (358 mg): 1H NMR (DMSO-d6) 4.27 (2H, s), 4.47-4.32 (2H, m), 4.70-4.56 (1H, m), 4.91 (1H, s), 5.92 (1H, d), 6.23 (1H, t), 7.50 (3H, m), 7.74 (2H, d), 8.15 (1H, d), 8.84 (1H, d), 8.91 (1H, s); m/z 363.1 (M+H)+.

Sources & evidence

ORD record: ord-89e5056d537f49c59b9b8816b51930b6
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09206126B2

Reaction notes

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