Hydrochloric Acid → HCID 67367332, compound

Participants

Reaction Steps

HCl gas was passed through a solution of 9 g (1 eq) 4-phenyl-4-(pyrrolidin-1-yl)piperidine in 180 ml chloroform for ˜30 min until the reaction mixture reached a pH of ˜2. The reaction course was monitored by thin-layer chromatography (10% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and the residue washed with ethyl acetate (3×100 ml) and dried. 9 g (76%) of product were obtained in the form of a solid.

Provenance & Evidence