Hydrochloric Acid → HCID 67367332, compound

HRID 1500322Notes

Reaction equation

HRID 1500322 reaction equation
[ClH:1].[C:2]1([C:8]2([N:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.C(Cl)(Cl)[Cl:22]>C(Cl)(Cl)Cl>[ClH:22].[ClH:1].[C:2]1([C:8]2([N:14]3[CH2:15][CH2:16][CH2:17][CH2:18]3)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21584188Chloroform methanolHCID 594016893543-21-3

Product 1

HCID 67367332HCID 67367332, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

HCl gas was passed through a solution of 9 g (1 eq) 4-phenyl-4-(pyrrolidin-1-yl)piperidine in 180 ml chloroform for ˜30 min until the reaction mixture reached a pH of ˜2. The reaction course was monitored by thin-layer chromatography (10% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and the residue washed with ethyl acetate (3×100 ml) and dried. 9 g (76%) of product were obtained in the form of a solid.

Workup

  1. customthe solvent was removed under reduced pressure
  2. washthe residue washed with ethyl acetate (3×100 ml)
  3. customdried

Sources & evidence

ORD record
ord-f6f550c869ec420dba84cd89b2b6785a
Source dataset
uspto-grants-2015_12
Patent number
US09206156B2

Reaction notes

Loading…