Hydrochloric Acid → HCID 86633673, compound

HRID 1500324Notes

Reaction equation

HRID 1500324 reaction equation
[ClH:1].[CH3:2][N:3]([CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:15][CH2:14]1)[C:4](=[O:10])[O:5][C:6]([CH3:9])([CH3:8])[CH3:7].CO.C(Cl)(Cl)[Cl:33]>C(Cl)(Cl)Cl>[ClH:33].[ClH:1].[ClH:33].[CH3:2][N:3]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:17][CH2:18]1)[C:4](=[O:10])[O:5][C:6]([CH3:9])([CH3:7])[CH3:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21584188Chloroform methanolHCID 68408166HCID 68408166, compound

Product 1

HCID 86633673HCID 86633673, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

HCl gas was passed through a solution of 8 g (1 eq) tert-butyl methyl(2-(4-phenyl-4-(pyrrolidin-1-yl)piperidin-1-yl)ethyl)carbamate in 160 ml chloroform at 0° C. for ˜30 min until the reaction mixture reached a pH of ˜2. The reaction mixture was then stirred at room temperature for 4 hours. The reaction course was monitored by thin-layer chromatography (10% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and 8 g (97%) of product were obtained in the form of a white solid.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-26ad4b8ea92943a6a759333bd9940115
Source dataset
uspto-grants-2015_12
Patent number
US09206156B2

Reaction notes

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