反应详情

HCl gas was passed through a solution of 9 g (1 eq) tert-butyl 3-(4-(dimethylamino)-4-phenylpiperidin-1-yl)propyl(methyl)carbamate in 100 ml chloroform at 0° C. for 1 h. The reaction course was monitored by thin-layer chromatography (20% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and after trituration with diethyl ether 10 g (100%) of product were obtained in the form of a white solid.

1. customthe solvent was removed under reduced pressure
2. customafter trituration with diethyl ether 10 g (100%) of product were obtained in the form of a white solid