反应详情

温度

27.5 °C

Sunitinib (2.0 g) was suspended in 10% methanol in dichloromethane (30 mL) at 25° C., followed by addition of malonic acid (0.29 g) .The reaction mass was maintained under stirring at 25-30° C. for 15 hrs. The solids obtained were filtered, suck dried and dried under vacuum for a period of 10 hrs at 60° C. to obtain sunitinib malonate. (2.0 g; yield: 80%)

1. temperaturewas maintained
2. customThe solids obtained
3. filtrationwere filtered
4. customsuck dried
5. customdried under vacuum for a period of 10 hrs at 60° C.