Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Sunitinib | HCID 5329102 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131734268 | HCID 131734268 | 80% |
Reaction Steps
Sunitinib (2.0 g) was suspended in 10% methanol in dichloromethane (30 mL) at 25° C., followed by addition of malonic acid (0.29 g) .The reaction mass was maintained under stirring at 25-30° C. for 15 hrs. The solids obtained were filtered, suck dried and dried under vacuum for a period of 10 hrs at 60° C. to obtain sunitinib malonate. (2.0 g; yield: 80%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09206163B2 |
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| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-1efdee7b095547cda3536fb765f6dfe4 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
