HRID1500390

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID971

Oxalic acid

C2H2O4

$反应SMILES：CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C$

HCID5329102

Sunitinib

C22H27FN4O2

PRODUCTS

产物

$反应SMILES：CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C.O=C([O-])CC(=O)[O-]$

HCID131734268

未命名化合物

收率 75%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度: 27.5 °C

PROCEDURE

实验过程

Sunitinib (1.0 g) was suspended in 10% methanol in dichloromethane (30mL) at 25° C. , followed by addition of oxalic acid (0.22 g) .The reaction mass was maintained under stirring at 25-30° C. for 60 minutes. The solids obtained were filtered, suck dried and dried under vacuum for a period of 10 hrs at 60° C. to obtain sunitinib malonate. (0.9 g; yield: 75%)

WORKUP

后处理

temperaturewas maintained
customThe solids obtained
filtrationwere filtered
customsuck dried
customdried under vacuum for a period of 10 hrs at 60° C.