Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | Sunitinib | HCID 5329102 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131734268 | HCID 131734268 | 75% |
Reaction Steps
Sunitinib (1.0 g) was suspended in 10% methanol in dichloromethane (30mL) at 25° C. , followed by addition of oxalic acid (0.22 g) .The reaction mass was maintained under stirring at 25-30° C. for 60 minutes. The solids obtained were filtered, suck dried and dried under vacuum for a period of 10 hrs at 60° C. to obtain sunitinib malonate. (0.9 g; yield: 75%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09206163B2 |
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| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-9e4db196189144d8bdfebfbe3bd82fc7 |
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| Source note | uspto-grants-2015_12 |
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