反应详情

温度

-78 °C

To a solution of 2-bromo-1-(2-bromoethoxy)-4-methylbenzene (1a) (1.0 g, 3.4 mmol) in THF (20 mL) at −78° C., under N2 was added n-BuLi (2.5 M, 11 mL, 27 mmol) and the resulting mixture was stirred at −78° C., for 1 h. The mixture was quenched with saturated NH4Cl (10 mL), extracted with EtOAc (150 mL), washed with brine, dried and concentrated to give the title compound (1b) as a colorless oil.

1. customThe mixture was quenched with saturated NH4Cl (10 mL)
2. extractionextracted with EtOAc (150 mL)
3. washwashed with brine
4. customdried
5. concentrationconcentrated