Hydrochloric Acid → HCID 178419350, compound

HRID 1500510Notes

Reaction equation

HRID 1500510 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][CH:19]=2)[N:17]=1)=O)(C)(C)C.Cl>CO>[Br:24][C:21]1[CH:20]=[CH:19][C:18]([C:16]2[N:17]=[C:13]([C@@H:9]3[CH2:10][CH2:11][CH2:12][NH:8]3)[NH:14][CH:15]=2)=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451912HCID 178451912, compound

Product 1

HCID 178419350HCID 178419350, compoundYield 113%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of (S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (3 g, 7.6 mmol) in methanol (3 mL) was added 4N HCl in methanol (60 mL) at 0° C. The reaction mixture was stirred for 2 h and then concentrated to give crude hydrochloride salt of the title compound (2.51 g 100% yield) as a yellow solid.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-9171b1f993bd4a00aa7ea447874d0d81
Source dataset
uspto-grants-2015_12
Patent number
US09206159B2

Reaction notes

Loading…