反应详情

温度

60 °C

To a mixture of 4-bromo-3-trifluoromethoxy-phenylamine (2.0 g, 7.8 mmol) in ACN (60 mL) was slowly added a solution of N-chlorosuccinimide (1.0 g, 7.8 mmol) in ACN (40 mL). The reaction mixture was heated to at 60° C. overnight and extracted with ethyl acetate/water. The organic layer was dried over sodium sulfate and purified by silica gel chromatography (40 g silica, 100% hexanes to 10% EtOAc: hexanes) to produce the desired product as an orange colored oil (1.4 g, 64% yield).

1. extractionextracted with ethyl acetate/water
2. dry with materialThe organic layer was dried over sodium sulfate
3. custompurified by silica gel chromatography (40 g silica, 100% hexanes to 10% EtOAc: hexanes)