Hydrochloric Acid → HCID 86725075, compound

HRID 1500537Notes

Reaction equation

HRID 1500537 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1[CH:4]=[C:5]1[S:9]C(=S)N[C:6]1=[O:11].[OH-:17].[Na+].Cl>O>[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:3]=1/[CH:4]=[C:5](\[SH:9])/[C:6]([OH:17])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 3096175HCID 3096175, compound

Product 1

HCID 86725075HCID 86725075, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 2,6-dichlorobenzylidenerhodanine (160.4 g) and water (800 ml) was stirred at room temperature, and sodium hydroxide (83.0 g) was added over a period of 1 hour. The resulting mixture was heated with stirring for another 0.5 hours. The reaction mixture was cooled with ice (10° C.), and concentrated hydrochloric acid (192 ml) was added. After the mixture was stirred while cooling with ice for 0.5 hours, the precipitated crystals were collected by filtration. The crystals obtained by filtration were washed with water and then dried to obtain an equivalent amount of (Z)-3-(2,6-dichlorophenyl)-2-mercapto-2-propenoic acid.

Workup

  1. temperatureThe resulting mixture was heated
  2. stirringwith stirring for another 0.5 hours
  3. additionwas added
  4. stirringAfter the mixture was stirred
  5. temperaturewhile cooling with ice for 0.5 hours
  6. filtrationthe precipitated crystals were collected by filtration
  7. customThe crystals obtained by filtration
  8. washwere washed with water
  9. customdried

Sources & evidence

ORD record
ord-2d38af0cf4314733a28e2ebd75f7ac1f
Source dataset
uspto-grants-2015_12
Patent number
US09206169B2

Reaction notes

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