Ethanol hydrochloride → HCID 66884092, compound

HRID 1500565Notes

Reaction equation

HRID 1500565 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=5)[CH2:24][CH2:23][C:22]4=[O:31])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.[Cl:32]CCCCCN1C2C(=CC=CC=2)CCC1=O.C(O)C.Cl>C(O)C>[ClH:32].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=5)[CH2:24][CH2:23][C:22]4=[O:31])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 21887872Ethanol hydrochlorideHCID 43348316HCID 43348316, compoundHCID 66884093HCID 66884093, compound

Product 1

HCID 66884092HCID 66884092, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By a similar method as in Example 1, 1-[5-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)pentyl]-3,4-dihydro-1H-quinolin-2-one was prepared from 1-(5-chloropentyl)-3,4-dihydro-1H-quinolin-2-one, and after it was made into an ethanol solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration and thereby 1-[5-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)pentyl]-3,4-dihydro-1H-quinolin-2-one hydrochloride was obtained.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration

Sources & evidence

ORD record
ord-9406a2c6869d47da9ff30968abca3f6b
Source dataset
uspto-grants-2015_12
Patent number
US09206167B2

Reaction notes

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