Methyl iodide → HCID 66886294, compound

HRID 1500571Notes

Reaction equation

HRID 1500571 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:29]=[C:28]5[C:23]([CH:24]=[CH:25][N:26]([CH3:31])[C:27]5=[O:30])=[CH:22][CH:21]=4)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.S1C=CC2C(N3CCN(CCCOC4C=C5C(C=CNC5=O)=CC=4)CC3)=CC=CC1=2.CI.C(O)C.[ClH:67]>C(OCC)(=O)C>[ClH:67].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]4[CH:29]=[C:28]5[C:23]([CH:24]=[CH:25][N:26]([CH3:31])[C:27]5=[O:30])=[CH:22][CH:21]=4)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 11978939HCID 11978939, compoundHCID 11978940HCID 11978940, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 66886294HCID 66886294, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By a similar method as in Example 18, 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-2H-isoquinolin-1-one was prepared from 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2H-isoquinolin-1-one using methyl iodide, and after it was made into an ethyl acetate solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from ethyl acetate and thereby 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-2H-isoquinolin-1-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-90794beb23a4456d96a6e0d875885744
Source dataset
uspto-grants-2015_12
Patent number
US09206167B2

Reaction notes

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