Acetic Acid → 2-Chloro-4-(2-ethyl-3-hydroxy-4-methyl-5-oxopyrrolidin-1-yl)benzonitrile
Reaction equation
[CH2:14]([Li:15])[CH2:16][CH2:17][CH3:18].[CH3:45][C:46](=[O:47])[OH:48].[CH3:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cl:19][c:20]1[c:21]([C:22]#[N:23])[cH:24][cH:25][c:26]([N:28]2[CH:29]([CH2:35][CH3:36])[CH:30]([OH:34])[CH2:31][C:32]2=[O:33])[cH:27]1.[I:37][CH3:38].[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1.[OH2:44]>>[CH3:1][CH:31]1[CH:30]([OH:34])[CH:29]([CH2:35][CH3:36])[N:28]([c:26]2[cH:25][cH:24][c:21]([C:22]#[N:23])[c:20]([Cl:19])[cH:27]2)[C:32]1=[O:33]Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-054ff64cbf0c45afb3ba8431b7933b25
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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