Hydrochloric Acid → HCID 178517562, compound

Participants

Reaction Steps

Aqueous hydrogen chloride (13 mL of a 6N solution, 78 mmol) was added to 3-(5-fluoro-4-methoxypyrimidin-2-yl)pyrazolo[1,5-a]pyrazine (Preparation 17a, 0.38 g, 1 mmol) in a microwave vessel. The resulting mixture was subjected to microwave irradiation for 1 hour at 120° C. After cooling to room temperature, 8N aqueous sodium hydroxide solution was added until a basic pH was reached. The solid formed was filtered and dried to yield the title compound (72%), which was used in the next step without further purification.

Provenance & Evidence