Hydrochloric Acid → HCID 178517562, compound

HRID 1500752Notes

Reaction equation

HRID 1500752 reaction equation
Cl.[F:2][C:3]1[C:4]([O:18]C)=[N:5][C:6]([C:9]2[CH:10]=[N:11][N:12]3[CH:17]=[CH:16][N:15]=[CH:14][C:13]=23)=[N:7][CH:8]=1.[OH-].[Na+]>>[F:2][C:3]1[C:4]([OH:18])=[N:5][C:6]([C:9]2[CH:10]=[N:11][N:12]3[CH:17]=[CH:16][N:15]=[CH:14][C:13]=23)=[N:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67327214HCID 67327214, compound

Product 1

HCID 178517562HCID 178517562, compoundYield 72%

Procedure

Aqueous hydrogen chloride (13 mL of a 6N solution, 78 mmol) was added to 3-(5-fluoro-4-methoxypyrimidin-2-yl)pyrazolo[1,5-a]pyrazine (Preparation 17a, 0.38 g, 1 mmol) in a microwave vessel. The resulting mixture was subjected to microwave irradiation for 1 hour at 120° C. After cooling to room temperature, 8N aqueous sodium hydroxide solution was added until a basic pH was reached. The solid formed was filtered and dried to yield the title compound (72%), which was used in the next step without further purification.

Workup

  1. customirradiation for 1 hour at 120° C
  2. customThe solid formed
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-dd0910d0ee6f447f8a2f41e70251d5ca
Source dataset
uspto-grants-2015_12
Patent number
US09206183B2

Reaction notes

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