Triethylamine → HCID 178526803, compound

HRID 1500758Notes

Reaction equation

HRID 1500758 reaction equation
Cl.[N:2]1[N:6]2[CH:7]=[CH:8][N:9]=[CH:10][C:5]2=[C:4]([C:11](=[NH:13])[NH2:12])[CH:3]=1.CN(C)/[CH:16]=[C:17](\[N+:23]([O-:25])=[O:24])/[C:18](OCC)=[O:19].C(N(CC)CC)C>C(O)C>[N+:23]([C:17]1[C:18]([OH:19])=[N:13][C:11]([C:4]2[CH:3]=[N:2][N:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:5]=23)=[N:12][CH:16]=1)([O-:25])=[O:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12247846HCID 12247846, compoundHCID 67123879HCID 67123879, compound

Product 1

HCID 178526803HCID 178526803, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of crude pyrazolo[1,5-a]pyrazine-3-carboximidamide hydrochloride (Preparation 24c, 4.88 g), (Z)-ethyl 3-(dimethylamino)-2-nitroacrylate (8.04 g, 42.7 mmol) and triethylamine (6.25 mL, 44.8 mmol) in ethanol (165 mL) was stirred and heated to 90° C. in a sealed tube. After 22 hours, the reaction mixture was cooled and the precipitate was filtered, washed with ethanol and diethyl ether and dried to give the title compound (3.12 g, 66%) as a yellow solid.

Workup

  1. temperaturethe reaction mixture was cooled
  2. filtrationthe precipitate was filtered
  3. washwashed with ethanol and diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-b10cb5b035f44ecdaf67332fcf630ffe
Source dataset
uspto-grants-2015_12
Patent number
US09206183B2

Reaction notes

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